Het-PDB Navi2 (PDB: 2QN1)

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Ligands
Code	Name		Style	Show	Link
0AS	Asiatic acid				PoSSuM

Non-standard Residues
Code	Name	Show
LLP	(2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid

Glycosylation
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Modification
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Download interaction data: 2QN1

Code :

2QN1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE, APOPTOSIS

Title :

Glycogen Phosphorylase B in complex with asiatic acid

Release Data :

2008-06-03

Compound :

mol_id	molecule	chains	synonym
1	Glycogen phosphorylase, muscle form	A	Glycogen Phosphorylase b; Myophosphorylase
	ec: 2.4.1.1

Source :

mol_id	organism_scientific	organism_common
1	Oryctolagus cuniculus	Rabbit
	other_details: Muscle, gene PYGM

Authors :

Zographos, S.E., Leonidas, D.D., Alexacou, K.-M., Hayes, J., Oikonomakos, N.G.

Keywords :

glycogenolysis, type 2 diabetes, TRANSFERASE, APOPTOSIS

Exp. method :

X-RAY DIFFRACTION ( 2.401 Å )

Citation :

Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies

Wen, X.,Sun, H.,Liu, J. et al.
(2008) J.Med.Chem. 51 : 3540 - 3554

PubMed: 18517260
DOI: 10.1021/jm8000949

Chain :

UniProt :

P00489 (PYGM_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate	2.4.1.1	UniProtKB:P11217
	left-to-right	UniProtKB:P11217

PDB ID: 2QN1

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Structure summary

Reaction