PDB ID: 2QHX
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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FE1 | Methyl 1-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)piperidine-4-carboxylate | PoSSuM | |||
IOD | Iodide ion | PoSSuM | |||
NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 2QHX
Structure summary
Code : | 2QHX PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Structure of Pteridine Reductase from Leishmania major complexed with a ligand | ||||||||||||
Release Data : | 2007-12-25 | ||||||||||||
Compound : |
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Authors : | Gibellini, F., Mcluskey, K., Tulloch, L., Hunter, W.N. | ||||||||||||
Keywords : | oxidoreductase, short-chain dehydrogenase/reductase, pteridine reductase, trypanosomatid, pterin salvage, drug resistance, methotrexate resistance, enzyme inhibitor, NADP/NADPH | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.61 Å ) | ||||||||||||
Citation : |
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
Cavazzuti, A.,Paglietti, G.,Hunter, W.N.
et al.
PubMed: 18245389 |
Reaction
Chain : | A, B, C, D | ||||||||
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UniProt : | Q01782 (PTR1_LEIMA) | ||||||||
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