PDB ID: 2QCM
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Structure summary
Code : | 2QCM PDBj RCSB PDB PDBe | ||||||||||||
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Header : | LYASE | ||||||||||||
Title : | Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to 6-hydroxymethyl-UMP | ||||||||||||
Release Data : | 2007-11-06 | ||||||||||||
Compound : |
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Source : |
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Authors : | Wittmann, J., Rudolph, M. | ||||||||||||
Keywords : | UMP synthase, decarboxylase, catalytic proficiency, Lyase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.67 Å ) | ||||||||||||
Citation : |
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Wittmann, J.G.,Heinrich, D.,Gasow, K.
et al.
PubMed: 18184586 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P11172 (UMPS_HUMAN) | ||||||||||||
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