Brand  (β version)

PDB ID: 2Q7G

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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate PoSSuM
CCL N~6~-[(cyclopentyloxy)carbonyl]-D-lysine PoSSuM
EDO 1,2-ethanediol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2Q7G   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Pyrrolysine tRNA Synthetase bound to a pyrrolysine analogue (cyc) and ATP
Release Data : 2007-07-24
Compound :
mol_id molecule chains synonym
1 Pyrrolysyl-tRNA synthetase A Pyrrolysine--tRNA ligase, PylRS
ec: 6.1.1.-
fragment: C-terminal domain
Source :
mol_id organism_scientific expression_system
1 Methanosarcina mazei  (taxid:2209) Escherichia coli  (taxid:562)
gene: pylS
expression_system_strain: BL21 CODON-PLUS RIL (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pet15b
Authors : Kavran, J.M., Steitz, T.A.
Keywords : pyrrolysyl-tRNA syntethetase, pyrrolysine, LIGASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.

Kavran, J.M.,Gundllapalli, S.,O'donoghue, P.  et al.
(2007)  Proc.Natl.Acad.Sci.Usa  104 : 11268 - 11273

PubMed: 17592110
DOI: 10.1073/pnas.0704769104

Reaction

Chain : A
UniProt : Q8PWY1 (PYLS_METMA)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L- pyrrolysyl-tRNA(Pyl) 6.1.1.26 HAMAP- Rule:MF_01573
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