Brand  (β version)

PDB ID: 2Q1J

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FXI 1-(butyl{[(4-chlorophenyl)amino]carbonyl}amino)-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]cyclopropanecarboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Q1J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The discovery of glycine and related amino acid-based factor xa inhibitors
Release Data : 2007-08-14
Compound :
mol_id molecule chains
1 Activated factor Xa heavy chain (EC 3.4.21.6) A
ec: 3.4.21.6
mol_id molecule chains
2 Factor X light chain (EC 3.4.21.6) B
ec: 3.4.21.6
fragment: Residues 128-178
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Kohrt, J.T., Filipski, K.J., Cody, W.L., Bigge, C.F., Zhang, E., Finzel, B.C.
Keywords : COAGULATION FXA, Blood coagulation, Calcium, Cleavage on pair of basic residues, EGF-like domain, Gamma-carboxyglutamic acid, Glycoprotein, Hydrolase, Hydroxylation, Polymorphism, Protease, Serine protease, Zymogen
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors

Kohrt, J.T.,Filipski, K.J.,Cody, W.L.  et al.
(2006)  BIOORG.MED.CHEM.  14 : 4379 - 4392

PubMed: 16529937
DOI: 10.1016/j.bmc.2006.02.040

Reaction

Chain : B
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
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