PDB ID: 2PK5
Hetero Atom Contents
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075 | (4r)-N-[(1s,2r)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]-3-[(2s,3s)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-3-(methyl sulfonyl)-L-alanyl}amino)-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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Download interaction data: 2PK5
Structure summary
Code : | 2PK5 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075 | ||||||||||||
Release Data : | 2007-05-08 | ||||||||||||
Compound : |
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Authors : | Armstrong, A.A., Lafont, V., Kiso, Y., Freire, E., Amzel, L.M. | ||||||||||||
Keywords : | PROTEASE COMPLEX, Viral Protein, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.900 Å ) | ||||||||||||
Citation : |
Compensating enthalpic and entropic changes hinder binding affinity optimization.
Lafont, V.,Armstrong, A.A.,Ohtaka, H.
et al.
PubMed: 17581235 |
Reaction
Chain : | A, B | ||||||||||||||||||||||||
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UniProt : | P03367 (POL_HV1BR) | ||||||||||||||||||||||||
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