Brand  (β version)

PDB ID: 2PJL

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
047 1-cyclohexyl-N-{[1-(4-methylphenyl)-1h-indol-3-yl]methyl}methanamine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2PJL   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism
Release Data : 2007-06-12
Compound :
mol_id molecule chains synonym
1 Steroid hormone receptor ERR1 A,B Estrogen-related receptor, alpha, ERR- alpha, Estrogen receptor-like 1
fragment: ligand binding domain
mutation: C325S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ESRRA, ERR1, ESRL1, NR3B1
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: baculovirus
Authors : Kallen, J.
Keywords : nuclear hormone receptor, ligand binding domain, ligand binding pocket, three-layered alpha-helical sandwich, inverse agonist, helix 12 (H12), coactivator groove, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.

Kallen, J.,Lattmann, R.,Beerli, R.  et al.
(2007)  J.Biol.Chem.  282 : 23231 - 23239

PubMed: 17556356
DOI: 10.1074/jbc.M703337200

Reaction

Chain : A, B
UniProt : P11474 (ERR1_HUMAN)
Reaction : -