PDB ID: 2P4Y
Hetero Atom Contents
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C03 | (2r)-2-(4-chloro-3-{[3-(6-methoxy-1,2-benzisoxazol-3-yl)-2-methyl-6-(trifluoromethoxy)-1h-indol-1-yl]methyl}phenoxy)propanoic acid | PoSSuM | |||
TRS | 2-amino-2-hydroxymethyl-propane-1,3-diol | PoSSuM |
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Download interaction data: 2P4Y
Structure summary
Code : | 2P4Y PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||
Title : | Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator | ||||||||||||
Release Data : | 2008-01-08 | ||||||||||||
Compound : |
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Source : |
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Authors : | McKeever, B.M. | ||||||||||||
Keywords : | NUCLEAR RECEPTOR, LIGAND BINDING DOMAIN, LBD, ALPHA HELIX SANDWICH, PPAR-HOMODIMER, SPPARgM, PARTIAL AGONIST, TRANSCRIPTION | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.25 Å ) | ||||||||||||
Citation : |
The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Einstein, M.,Akiyama, T.E.,Castriota, G.A.
et al.
PubMed: 17940191 |
Reaction
Chain : | A, B |
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UniProt : | P37231 (PPARG_HUMAN) |
Reaction : | - |