PDB ID: 2P3T
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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993 | 3-chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide | PoSSuM | |||
CA | Calcium ion | PoSSuM | |||
CL | Chloride ion | PoSSuM |
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Download interaction data: 2P3T
Structure summary
Code : | 2P3T PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | BLOOD CLOTTING | ||||||||||||||||||||||||
Title : | Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide | ||||||||||||||||||||||||
Release Data : | 2008-01-22 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Adler, M., Whitlow, M. | ||||||||||||||||||||||||
Keywords : | protein inhibitor complex, nonamidine, coagulation cofactor, protease, BLOOD CLOTTING | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.92 Å ) | ||||||||||||||||||||||||
Citation : |
Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors.
Ye, B.,Arnaiz, D.O.,Chou, Y.L.
et al.
PubMed: 17536795 Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa
Adler, M.,Kochanny, M.J.,Bin, Y.
et al.
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa
Kochanny, M.J.,Adler, M.,Ewing, J.
et al.
Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors
Chou, Y.L.,Davey, D.D.,Eagen, K.A.
et al.
Preparation, Characterization and the Crystal Structure of the Inhibitor ZK-807834 (Ci-1031) Complexed with Factor Xa
Adler, M.,Davey, D.D.,Phillips, G.B.
et al.
Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors
Maignan, S.,Guilloteau, J.P.,Pouzieux, S.
et al.
Discovery of N-[2-[5-[Amino(Imino)Methyl]-2-Hydroxyphenoxy]-3,5-Difluoro- 6-[3-(4,5-Dihydro-1-Methyl-1H-Imidazol-2-Yl)Phenoxy]Pyridin-4-Yl]-N-Methylglycine (Zk-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa
Phillips, G.B.,Buckman, B.O.,Davey, D.D.
et al.
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Reaction
Chain : | B | ||||||||
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UniProt : | P00742 (FA10_HUMAN) | ||||||||
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