Brand  (β version)

PDB ID: 2OAZ

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
I96 N-(2-isopropylphenyl)-3-[(2-thienylmethyl)thio]-1h-1,2,4-triazol-5-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2OAZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human Methionine Aminopeptidase-2 Complexed with SB-587094
Release Data : 2007-06-19
Compound :
mol_id molecule chains
1 human Methionine Amino Peptidase 2 A
ec: 3.4.11.18
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Marino Jr., J.P., Fisher, P.W., Hofmann, G.A., Kirkpatrick, R., Janson, C.A., Johnson, R.K., Ma, C., Mattern, M., Meek, T.D., Ryan, D., Schulz, C., Smith, W.W., Tew, D.G., Tomazek Jr., T.A., Veber, D.F., Xiong, W.C., Yamamoto, Y., Yamashita, K., Yang, G., Thompson, S.K.
Keywords : MetAP2, Methionine, Amino Peptidase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Marino, J.P.,Fisher, P.W.,Hofmann, G.A.  et al.
(2007)  J.Med.Chem.  50 : 3777 - 3785

PubMed: 17636946
DOI: 10.1021/jm061182w

Reaction

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03175, PubMed:20521764
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