Brand  (β version)

PDB ID: 2O4K

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
DR7 (3s,8s,9s,12s)-3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5, 6,10,13-pentaazatetradecanedioic acid dimethyl ester PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 2O4K   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir
Release Data : 2006-12-12
Compound :
mol_id molecule chains
1 protease A,B
mutation: Q7K
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli BL21(DE3)  (taxid:469008)
strain: Subtype B
gene: gag-pol
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24
Authors : Armstrong, A.A., Muzammil, S., Jakalian, A., Bonneau, P.R., Schmelmer, V., Freire, E., Amzel, L.M.
Keywords : protease complex, Viral protein
Exp. method : X-RAY DIFFRACTION ( 1.600 Å )
Citation :

Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.

Muzammil, S.,Armstrong, A.A.,Kang, L.W.  et al.
(2007)  J.Virol.  81 : 5144 - 5154

PubMed: 17360759
DOI: 10.1128/JVI.02706-06

Reaction

Chain : A, B
UniProt : P03367 (POL_HV1BR)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 -
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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