Brand  (β version)

PDB ID: 2O3R

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Ligands
Code Name Style Show Link
CXR Cyclic adenosine diphosphate-ribose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2O3R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
Release Data : 2006-12-12
Compound :
mol_id molecule chains synonym
1 ADP-ribosyl cyclase 1 A,B Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Lymphocyte differentiation antigen CD38, T10, Acute lymphoblastic leukemia cells antigen CD38
ec: 3.2.2.5
fragment: Extracellular domain, residues 45-300
mutation: Q49T, N100D, N164D, N209D, N219D, E226D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
gene: CD38
expression_system_strain: X-33
expression_system_vector_type: PLASMID
expression_system_plasmid: pPICZaA
Authors : Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C., Hao, Q.
Keywords : Human CD38 E226D mutant, the catalytic pocket, cADPR formation and hydrolysis, substrate binding, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38

Liu, Q.,Kriksunov, I.A.,Graeff, R.  et al.
(2007)  J.Biol.Chem.  282 : 5853 - 5861

PubMed: 17182614
DOI: 10.1074/jbc.M609093200

Reaction

Chain : A, B
UniProt : P28907 (CD38_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate - PubMed:16690024
right-to-left
NAD(+) = cyclic ADP-beta-D-ribose + nicotinamide + H(+) - PubMed:7961800, PubMed:8253715
left-to-right PubMed:8253715
NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+) 3.2.2.6 PubMed:16690024, PubMed:8253715
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cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose - PubMed:7961800, PubMed:8253715
left-to-right PubMed:8253715
NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide - PubMed:16690024
-
nicotinate + NADP(+) = nicotinate-adenine dinucleotide phosphate + nicotinamide 2.4.99.20 PubMed:16690024
left-to-right