Het-PDB Navi2 (PDB: 2O0U)

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Ligands
Code	Name		Style	Show	Link
C0M	N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-C]pyridin-2-yl}1-naphthalenecarboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2O0U

Code :

2O0U PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-C]pyridin-2-yl}-1-naphthalenecarboxamide

Release Data :

2007-02-27

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
	ec: 2.7.11.24 fragment: residues 39-402

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK10, JNK3, JNK3A, PRKM10

Authors :

Rowland, P., Somers, D.

Keywords :

Kinase fold, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.

Angell, R.M.,Atkinson, F.L.,Brown, M.J. et al.
(2007) Bioorg.Med.Chem.Lett. 17 : 1296 - 1301

PubMed: 17194588
DOI: 10.1016/j.bmcl.2006.12.003

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 2O0U

Hetero Atom Contents

Structure summary

Reaction