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Ligands
Code Name Style Show Link
902 {[5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phenyl)-4-bromo-2-(2h-tetrazol-5-yl)-3-thienyl]oxy}acetic acid
Non-standard Residues
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Glycosylation
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Code : 2NT7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of PTP1B-inhibitor complex
Release Data : 2007-04-17
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein phosphatase non-receptor type 1 A Protein-tyrosine phosphatase 1B, PTP-1B
ec: 3.1.3.48
fragment: catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PTPN1, PTP1B
Authors : Xu, W., Follows, B.
Keywords : PTP1B, protein-inhibitor complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Probing acid replacements of thiophene PTP1B inhibitors.

Wan, Z.K.,Follows, B.,Kirincich, S.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 2913 - 2920

PubMed: 17336064
DOI: 10.1016/j.bmcl.2007.02.043

Chain : A
UniProt : P18031 (PTN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PROSITE- ProRule:PRU10044
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