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Ligands
Code Name Style Show Link
C2R 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1h-imidazole-4-carboxylic acid
Non-standard Residues
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Glycosylation
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Code : 2NSJ   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : E. coli PurE H45Q mutant complexed with CAIR
Release Data : 2007-04-24
Compound :
mol_id molecule chains synonym
1 Phosphoribosylaminoimidazole carboxylase catalytic subunit A AIR carboxylase, AIRC
ec: 4.1.1.21
mutation: H45Q
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: purE
Authors : Ealick, S.E., Morar, M.
Keywords : central three-layer alpha-beta-alpha sandwich, kinked C-terminal helix, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.31 Å )
Citation :

N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.

Hoskins, A.A.,Morar, M.,Kappock, T.J.  et al.
(2007)  Biochemistry  46 : 2842 - 2855

PubMed: 17298082
DOI: 10.1021/bi602436g

Chain : A
UniProt : P0AG18 (PURE_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate 5.4.99.18 HAMAP- Rule:MF_01929, PubMed:10074353, PubMed:8117684
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