Het-PDB Navi2 (PDB: 2LB2)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
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Download interaction data: 2LB2

Code :

2LB2 PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/TRANSCRIPTION

Title :

Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3

Release Data :

2011-07-06

Compound :

mol_id	molecule	chains	synonym
1	E3 ubiquitin-protein ligase NEDD4-like	A	NEDD4.2, Nedd4-2
	ec: 6.3.2.- fragment: residues 386-420

mol_id	molecule	chains	synonym
2	Mothers against decapentaplegic homolog 3	B	MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3
	fragment: residues 178-189

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: NEDD4L, KIAA0439, NEDL3 expression_system_vector: pETM11

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Macias, M.J., Aragon, E., Goerner, N., Zaromytidou, A., Xi, Q., Escobedo, A., Massague, J.

Keywords :

Nedd4L, SMAD, CDK, signal transduction, SIGNALING PROTEIN-TRANSCRIPTION complex

Exp. method :

SOLUTION NMR

Citation :

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

Aragon, E.,Goerner, N.,Zaromytidou, A.I. et al.
(2011) Genes Dev. 25 : 1275 - 1288

PDB ID: 2LB2