Brand  (β version)

PDB ID: 2KH6

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
CTG (5r,6s)-5,6-dihydro-5,6-dihydroxythymidine-5'-monophosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2KH6   PDBj   RCSB PDB   PDBe
Header : DNA
Title : Solution Structure of cis-5R,6S-thymine glycol opposite complementary adenine in duplex DNA
Release Data : 2010-03-02
Compound :
mol_id molecule chains
1 5'-D(*GP*TP*GP*CP*GP*(CTG)P*GP*TP*TP*TP*GP*T)-3' A
mol_id molecule chains
2 5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3' B
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
Authors : Brown, K.L.
Keywords : Thymine Glycol, DNA
Exp. method : SOLUTION NMR
Citation :

Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site

Brown, K.L.,Roginskaya, M.,Zou, Y.  et al.
(2010)  Nucleic Acids Res.  38 : 428 - 440

PubMed: 19892827
DOI: 10.1093/nar/gkp844