Brand  (β version)

PDB ID: 2JT6

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
JT6 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2JT6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-N-hdydroxypropionamide (MMP-3 inhibitor VII)
Release Data : 2008-02-19
Compound :
mol_id molecule chains synonym
1 Stromelysin-1 A Matrix metalloproteinase-3, MMP-3, Transin-1, SL-1
ec: 3.4.24.17
fragment: sequence database residues 105-265
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MMP3, STMY1
expression_system_strain: BL21(DE3)
expression_system_vector_type: vector
expression_system_vector: pET21A
Authors : Alcaraz, L.A., Banci, L., Bertini, I., Cantini, F., Donaire, A., Gonnelli, L.
Keywords : metalloproteinase, MMP, Calcium, Collagen degradation, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Zinc, Zymogen
Exp. method : SOLUTION NMR
Citation :

Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors

Alcaraz, L.A.,Banci, L.,Bertini, I.  et al.
(2007)  J.Biol.Inorg.Chem.  12 : 1197 - 1206

PubMed: 17710450
DOI: 10.1007/s00775-007-0288-9

Reaction

Chain : A
UniProt : P08254 (MMP3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage where P1', P2' and P3' are hydrophobic residues. 3.4.24.17 PubMed:1371271, PubMed:21330369
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