Brand  (β version)

PDB ID: 2JPR

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Ligands
Code Name Style Show Link
JPR 1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2JPR   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1
Release Data : 2007-10-09
Compound :
mol_id molecule chains synonym
1 Gag-Pol polyprotein A Pr160Gag-Pol
fragment: sequence database residues, 133-277
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)  (taxid:11698) Escherichia coli  (taxid:562)
gene: gag-pol
expression_system_vector_type: vector
expression_system_vector: pln4-3
Authors : Kelly, B.N., Kyere, S., Kinde, I., Tang, C., Howard, B.R., Robinson, H., Sundquist, W.I., Summers, M.F., Hill, C.P.
Keywords : cap-1, capsid, HIV-1, assembly inhibitor, VIRAL PROTEIN
Exp. method : SOLUTION NMR
Citation :

Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein

Kelly, B.N.,Kyere, S.,Kinde, I.  et al.
(2007)  J.Mol.Biol.  373 : 355 - 366

PubMed: 17826792
DOI: 10.1016/j.jmb.2007.07.070

Reaction

Chain : A
UniProt : P12497 (POL_HV1N5)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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