Brand  (β version)

PDB ID: 2JAM

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
J60 5-[(E)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2JAM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human calmodulin-dependent protein kinase I G
Release Data : 2007-03-13
Compound :
mol_id molecule chains synonym
1 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G A,B CAM KINASE IG, CAM KINASE I GAMMA, CAMKI GAMMA, CAMKI-GAMMA, CAM-KI GAMMA, CAMKIG, CAMK-LIKE CREB KINASE III, CLICK III, CALMODULIN-DEPENDENT, PROTEIN, KINASE, I, G
ec: 2.7.11.17
fragment: CATALYTIC DOMAIN, RESIDUES 18-316
mol_id molecule chains
2 POLYPEPTIDE D
mol_id molecule chains
3 POLYPEPTIDE E
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI BL21(DE3)  (taxid:469008)
expression_system_variant: R3 ROSETTA
expression_system_vector: PNIC28-BSA4
mol_id organism_scientific
2 UNIDENTIFIED  (taxid:32644)
other_details: UNKNOWN ORIGIN
mol_id organism_scientific
3 UNIDENTIFIED  (taxid:32644)
other_details: UNKNOWN ORIGIN
Authors : Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
Keywords : TRANSFERASE, KINASE, MEMBRANE, ATP-BINDING, PRENYLATION, SERINE/THREONINE-PROTEIN KINASE, ALTERNATIVE SPLICING, PROTEIN SERINE/THREONINE KINASE, CALMODULIN BINDING, CALMODULIN-BINDING, NUCLEOTIDE BINDING, NUCLEOTIDE-BINDING, LIPOPROTEIN, POLYMORPHISM, GOLGI APPARATUS, PHOSPHORYLATION, ALLOSTERIC ENZYME
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G

Debreczeni, J.E.,Bullock, A.,Keates, T.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : Q96NX5 (KCC1G_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.17 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.17 -
-