Brand  (β version)

PDB ID: 2IEI

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Ligands
Code Name Style Show Link
FRX (S)-2-chloro-N-(1-(2-(2-hydroxyethylamino)-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6h-thieno[2,3-B]pyrrole-5-carboxamide PoSSuM
PLR (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2IEI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone
Release Data : 2006-12-26
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A,B Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
Authors : Birch, A.M., Kenny, P.W., Oikonomakos, N.G., Otterbein, L., Schofield, P., Whittamore, P.R.O., Whalley, D.P., Rowsell, S., Pauptit, R., Pannifer, A., Breed, J., Minshull, C.
Keywords : GLYCOGEN PHOSPHORYLASE, DIABETES, GLUCOSE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.91 Å )
Citation :

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.

Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 394 - 399

PubMed: 17095214
DOI: 10.1016/j.bmcl.2006.10.037

Reaction

Chain : A, B
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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