Brand  (β version)

PDB ID: 2I4J

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Ligands
Code Name Style Show Link
DRJ (2r)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylbutanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2I4J   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of the complex between PPARgamma and the agonist LT160 (ureidofibrate derivative)
Release Data : 2007-04-17
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,B PPAR-gamma
fragment: ligand binding domain (LBD), residues 223-504
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PPARG, NR1C3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28
Authors : Pochetti, G., Mazza, F.
Keywords : bundle of alpha-helices and a small four-stranded beta-sheet, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

Pochetti, G.,Godio, C.,Mitro, N.  et al.
(2007)  J.Biol.Chem.  282 : 17314 - 17324

PubMed: 17403688
DOI: 10.1074/jbc.M702316200

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

Nolte, R.T.,Wisely, G.B.,Westin, S.  et al.
(1998)  Nature  395 : 137 - 143

PubMed: 9744270
DOI: 10.1038/25931

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

Oberfield, J.L.,Collins, J.L.,Holmes, C.P.  et al.
(1999)  Proc.Natl.Acad.Sci.USA  96 : 6102 - 6106

PubMed: 10339548
DOI: 10.1073/pnas.96.11.6102

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -