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Ligands
Code Name Style Show Link
H7J N-[(1s)-1-{1-[(1r,3e)-1-acetylpent-3-en-1-yl]-1h-1,2,3-triazol-4-yl}-1,2-dimethylpropyl]benzamide
P15 2,5,8,11,14,17-hexaoxanonadecan-19-ol
Non-standard Residues
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Code : 2H7J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.
Release Data : 2006-10-24
Compound :
mol_id molecule chains
1 Cathepsin S A,B
ec: 3.4.22.27
fragment: Cathepsin S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CTSS
expression_system_common: Fall armyworm
Authors : Patterson, A.W., Wood, W.J., Hornsby, M., Lesley, S., Spraggon, G., Ellman, J.A.
Keywords : CATHEPSIN S, Nonpeptidic, chloromethylketone, substrate activity screening, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.

Patterson, A.W.,Wood, W.J.,Hornsby, M.  et al.
(2006)  J.Med.Chem.  49 : 6298 - 6307

PubMed: 17034136
DOI: 10.1021/jm060701s

Chain : A, B
UniProt : P25774 (CATS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Similar to cathepsin L, but with much less activity on Z-Phe- Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. 3.4.22.27 -
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