Brand  (β version)

PDB ID: 2GRU

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Ligands
Code Name Style Show Link
CAK [(1r,2r,3s,4s,5r)-2,3,4,5-tetrahydroxycyclohexyl]methyl dihydrogen phosphate PoSSuM
CO Cobalt (II) ion PoSSuM
EXO (1r,2s,3s,4r)-5-methylenecyclohexane-1,2,3,4-tetraol PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
PO4 Phosphate ion PoSSuM
SO3 Sulfite ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2GRU   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of 2-deoxy-scyllo-inosose synthase complexed with carbaglucose-6-phosphate, NAD+ and Co2+
Release Data : 2007-05-08
Compound :
mol_id molecule chains
1 2-deoxy-scyllo-inosose synthase A,B
ec: 4.2.3.-
Source :
mol_id organism_scientific expression_system
1 Bacillus circulans  (taxid:1397) Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: PET30B
Authors : Nango, E., Kumasaka, T.
Keywords : aminoglycoside, 2-deoxystreptamine, dehydroquinate synthase, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+

Nango, E.,Kumasaka, T.,Hirayama, T.  et al.
(2008)  Proteins  70 : 517 - 527

PubMed: 17879343
DOI: 10.1002/prot.21526

Reaction

Chain : A, B
UniProt : Q9S5E2 (DOIS_NIACI)
Reaction: EC: Evidence:
Physiological Direction:
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate 4.2.3.124 PubMed:15788164, PubMed:9207913, PubMed:9972266
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