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Ligands
Code Name Style Show Link
FBR (9as)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3h-fluoren-3-one
Non-standard Residues
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Glycosylation
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Code : 2GIU   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION REGULATOR
Title : Human estrogen receptor beta ligand-binding domain in complex with compound 45
Release Data : 2006-10-10
Compound :
mol_id molecule chains synonym
1 Estrogen receptor beta A ER-beta
fragment: LIGAND-BINDING DOMAIN (Residues 260-500)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR2
Authors : Fitzgerald, P.M.D., Sharma, N.
Keywords : NUCLEAR RECEPTOR, TRANSCRIPTION FACTOR, ER-BETA, AGONIST, TRANSCRIPTION REGULATOR
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

Wilkening, R.R.,Ratcliffe, R.W.,Tynebor, E.C.  et al.
(2006)  Bioorg.Med.Chem.Lett.  16 : 3489 - 3494

PubMed: 16632357
DOI: 10.1016/j.bmcl.2006.03.098

Chain : A
UniProt : Q92731 (ESR2_HUMAN)
Reaction : -