Brand  (β version)

PDB ID: 2G8E

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Ligands
Code Name Style Show Link
0M6 N-[(2s)-1,4-dihydroxybutan-2-yl]-N~2~-(phenylcarbamothioyl)-L-leucinamide PoSSuM
CA Calcium ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
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Structure summary

Code : 2G8E   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Calpain 1 proteolytic core in complex with SNJ-1715, a cyclic hemiacetal-type inhibitor
Release Data : 2006-06-06
Compound :
mol_id molecule chains synonym
1 Calpain-1 catalytic subunit A Calpain-1 large subunit, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, muCANP, Micromolar-calpain
ec: 3.4.22.52
fragment: residues 27-356
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21  (taxid:511693)
gene: Capn1, Cls1
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: pET24d
Authors : Cuerrier, D., Moldoveanu, T., Davies, P.L., Campbell, R.L.
Keywords : protease, peptidase, inhibitor, cyclic hemiacetal, aldehyde, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography

Cuerrier, D.,Moldoveanu, T.,Inoue, J.  et al.
(2006)  Biochemistry  45 : 7446 - 7452

PubMed: 16768440
DOI: 10.1021/bi060425j

Reaction

Chain : A
UniProt : P97571 (CAN1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity. 3.4.22.52 UniProtKB:P07384
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