Brand  (β version)

PDB ID: 2FYU

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Ligands
Code Name Style Show Link
FDN (5s)-3-anilino-5-(2,4-difluorophenyl)-5-methyl-1,3-oxazolidine-2,4-dione PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2FYU   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
Release Data : 2006-08-29
Compound :
mol_id molecule chains
1 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial A
ec: 1.10.2.2
fragment: Core1
mol_id molecule chains synonym
2 Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial B Complex III subunit II
ec: 1.10.2.2
fragment: Core2
mol_id molecule chains
3 Cytochrome b C
fragment: cytochrome b
mol_id molecule chains synonym
4 Cytochrome c1, heme protein, mitochondrial D Cytochrome c-1
fragment: cytochrome c1
mol_id molecule chains synonym
5 Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial E RISP
ec: 1.10.2.2
fragment: Iron-sulfur protein
mol_id molecule chains
6 Hypothetical protein LOC616871 F
fragment: subunit 6
mol_id molecule chains synonym
7 Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C G Ubiquinol-cytochrome c reductase complex 9.5 kDa protein, Complex III subunit VII
ec: 1.10.2.2
fragment: subunit 7
mol_id molecule chains synonym
8 Ubiquinol-cytochrome c reductase complex 11 kDa protein H Mitochondrial hinge protein, Cytochrome C1, nonheme 11 kDa protein, Complex III subunit VIII
ec: 1.10.2.2
fragment: subunit 8
mol_id molecule chains
9 Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial I
fragment: Iron-sulfur protein signal sequence
mol_id molecule chains synonym
10 Ubiquinol-cytochrome c reductase complex 7.2 kDa protein J Cytochrome C1, nonheme 7 kDa protein, Complex III subunit X
ec: 1.10.2.2
fragment: subunit 10
mol_id molecule chains synonym
11 Ubiquinol-cytochrome c reductase complex 6.4 kDa protein K Complex III subunit XI
ec: 1.10.2.2
fragment: subunit 11
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
3 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
4 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
5 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
6 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
7 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
8 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
9 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
10 Bos taurus  (taxid:9913) Cattle
mol_id organism_scientific organism_common
11 Bos taurus  (taxid:9913) Cattle
Authors : Xia, D., Esser, L.
Keywords : Transmembrane helices, 11 protein complex, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.26 Å )
Citation :

Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc1 complex.

Esser, L.,Gong, X.,Yang, S.  et al.
(2006)  Proc.Natl.Acad.Sci.Usa  103 : 13045 - 13050

PubMed: 16924113
DOI: 10.1073/pnas.0601149103

Reaction

Chain : A
UniProt : P31800 (QCR1_BOVIN)
Reaction : -
Chain : B
UniProt : P23004 (QCR2_BOVIN)
Reaction : -
Chain : C
UniProt : P00157 (CYB_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
heme b ECO:0000269 | PubMed:12269811
ECO:0000269 | PubMed:15312779
ECO:0000269 | PubMed:16024040
ECO:0000269 | PubMed:16924113
ECO:0000269 | PubMed:9204897
ECO:0000269 | PubMed:9651245
Binds 2 heme b groups non-covalently.
Chain : D
UniProt : P00125 (CY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) 7.1.1.8 UniProtKB:P07143
-
Cofactor: Evidence: Note:
heme c ECO:0000269 | PubMed:9651245
Binds 1 heme c group covalently per subunit.
Chain : I
UniProt : P13272 (UCRI_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) 7.1.1.8 UniProtKB:P08067
-
Cofactor: Evidence: Note:
[2Fe-2S] cluster ECO:0000269 | PubMed:9651245
Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7).
Chain : F
UniProt : P00129 (QCR7_BOVIN)
Reaction : -
Chain : G
UniProt : P13271 (QCR8_BOVIN)
Reaction : -
Chain : H
UniProt : P00126 (QCR6_BOVIN)
Reaction : -
Chain : J
UniProt : P00130 (QCR9_BOVIN)
Reaction : -
Chain : K
UniProt : P07552 (QCR10_BOVIN)
Reaction : -