Brand  (β version)

PDB ID: 2FWW

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
C1R 4-piperidinebutyrate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2FWW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : human beta-tryptase II complexed with 4-piperidinebutyrate to make acylenzyme
Release Data : 2006-02-14
Compound :
mol_id molecule chains synonym
1 Tryptase beta-2 A,B,C,D Tryptase-2, Tryptase II
ec: 3.4.21.59
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
gene: TPSB2, TPS2
Authors : Katz, B.A.
Keywords : serine protease, proteinase, 29382, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Structure-guided design of Peptide-based tryptase inhibitors.

McGrath, M.E.,Sprengeler, P.A.,Hirschbein, B.  et al.
(2006)  Biochemistry  45 : 5964 - 5973

PubMed: 16681368
DOI: 10.1021/bi060173m

Reaction

Chain : A, B, C, D
UniProt : P20231 (TRYB2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin. 3.4.21.59 -
-