Brand  (β version)

PDB ID: 2FTN

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
Non-standard Residues
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CXM N-carboxymethionine
Glycosylation
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Structure summary

Code : 2FTN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : E. coli thymidylate synthase Y94F mutant
Release Data : 2006-05-02
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A TS, TSase
ec: 2.1.1.45
mutation: Y94F
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: thyA
expression_system_strain: Xac25 Thy
expression_system_vector_type: plasmid
expression_system_plasmid: BLUSCRIPT SK+
Authors : Montfort, W.R., Roberts, S.A.
Keywords : methyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Structure of the Y94F mutant of Escherichia coli thymidylate synthase.

Roberts, S.A.,Hyatt, D.C.,Honts, J.E.  et al.
(2006)  ACTA CRYSTALLOGR.,SECT.F  62 : 840 - 843

PubMed: 16946460
DOI: 10.1107/S1744309106029691

Reaction

Chain : A
UniProt : P0A884 (TYSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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