Brand  (β version)

PDB ID: 2FIT

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
FRU Beta-D-fructofuranose PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 2FIT   PDBj   RCSB PDB   PDBe
Header : CHROMOSOMAL TRANSLOCATION
Title : FHIT (FRAGILE HISTIDINE TRIAD PROTEIN)
Release Data : 1997-11-19
Compound :
mol_id molecule chains synonym
1 FRAGILE HISTIDINE PROTEIN A FHIT, FRAGILE HISTIDINE TRIAD PROTEIN
other_details: SELENOMETHIONYL FHIT WITH BOUND SULFATE IN ACTIVE SITE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FHIT
expression_system_strain: DL41
expression_system_plasmid: PGEX-2T
expression_system_gene: FHIT
other_details: EXPRESSED AS FUSION PROTEIN WITH GLUTATHIONE-S-TRANSFERASE
Authors : Lima, C.D., D'Amico, K.L., Naday, I., Rosenbaum, G., Westbrook, E.M., Hendrickson, W.A.
Keywords : FHIT, FRAGILE HISTIDINE TRIAD PROTEIN, PUTATIVE HUMAN TUMOR SUPPRESSOR, ADVANCED PHOTON SOURCE, APS, HIT PROTEIN FAMILY, PKCI, CHROMOSOMAL TRANSLOCATION
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.

Lima, C.D.,D'Amico, K.L.,Naday, I.  et al.
(1997)  Structure  5 : 763 - 774

PubMed: 9261067
DOI: 10.1016/S0969-2126(97)00231-1

Reaction

Chain : A
UniProt : P49789 (FHIT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+) 3.6.1.29 PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9543008, PubMed:9576908
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adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate 3.6.2.1 PubMed:18694747
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adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'- phosphoramidate + 2 H(+) + sulfate 2.7.7.51 PubMed:26181368
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adenosine 5'-phosphoramidate + H2O = AMP + NH4(+) - PubMed:18694747
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