Brand  (β version)

PDB ID: 2FDP

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Ligands
Code Name Style Show Link
FRP N1-((2s,3s,5r)-3-amino-6-(4-fluorophenylamino)-5-methyl-6-oxo-1-phenylhexan-2-yl)-n3,n3-dipropylisophthalamide PoSSuM
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Structure summary

Code : 2FDP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor
Release Data : 2006-01-24
Compound :
mol_id molecule chains synonym
1 Beta-secretase 1 A,B,C Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2
ec: 3.4.23.46
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: BACE1
expression_system_strain: BL21
expression_system_vector_type: PLASMID
Authors : Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D.
Keywords : ASPARTYL PROTEASE, BACE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

Yang, W.,Lu, W.,Lu, Y.  et al.
(2006)  J.Med.Chem.  49 : 839 - 842

PubMed: 16451048
DOI: 10.1021/jm0509142

Reaction

Chain : A, B, C
UniProt : P56817 (BACE1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. 3.4.23.46 PubMed:10677483
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