Het-PDB Navi2 (PDB: 2EJR)

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Ligands
Code	Name		Style	Show	Link
F2N	[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2r,3s,4s)-5-[7,8-dimethyl-2,4-dioxo-5-(3-phenylpropanoyl)-1,3,4,5-tetrahydrobenzo[G]pteridin-10(2h)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2EJR

Code :

2EJR PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

LSD1-tranylcypromine complex

Release Data :

2008-01-01

Compound :

mol_id	molecule	chains	synonym
1	Lysine-specific histone demethylase 1	A	Flavin-containing amine oxidase domain-containing protein 2, BRAF35-HDAC complex protein BHC110
	ec: 1.-.-.- fragment: LSD1, residues 172-833

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: KIAA0601, LSD1 expression_system_vector_type: PLASMID expression_system_plasmid: p-GEX-6P-1

Authors :

Sengoku, T., Mimasu, S., Umehara, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Keywords :

Tower domain, LSD1, FAD, Tranylcypromine, Parnate, amine oxidase, histone, demethylase, Alternative splicing, Chromatin regulator, Coiled coil, Nucleus, Oxidoreductase, Phosphorylation, Repressor, Transcription, Transcription regulation, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A

Mimasu, S.,Sengoku, T.,Fukuzawa, S. et al.
(2008) Biochem.Biophys.Res.Commun. 366 : 15 - 22

PubMed: 18039463
DOI: 10.1016/j.bbrc.2007.11.066

Chain :

UniProt :

O60341 (KDM1A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]	1.14.99.66	PubMed:15620353, PubMed:15811342
	-	PubMed:15620353, PubMed:15811342

PDB ID: 2EJR

Hetero Atom Contents

Structure summary

Reaction