Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
F77 3-ethyl-6-{[(4-fluorophenyl)sulfonyl]amino}-2-methylbenzoic acid
MN Manganese (II) ion
Code : 2EA2
Header : HYDROLASE
Title : H-MetAP2 complexed with A773812
Release Data : 2008-02-05
Compound :
mol_id molecule chains synonym
1 Methionine aminopeptidase 2 A MetAP 2, Peptidase M 2, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2
ec: 3.4.11.18
fragment: residues 110-478
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
Authors : Park, C.H.
Keywords : Protein-ligand complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids

Wang, G.T.,Mantei, R.A.,Kawai, M.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 2817 - 2822

PubMed: 17350258
DOI: 10.1016/j.bmcl.2007.02.062

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction : Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.