Brand  (β version)

PDB ID: 2E1W

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Ligands
Code Name Style Show Link
FR6 1-{(1r,2s)-2-hydroxy-1-[2-(1-naphthyl)ethyl]propyl}-1h-imidazole-4-carboxamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2E1W   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of adenosine deaminase complexed with potent inhibitors
Release Data : 2006-11-07
Compound :
mol_id molecule chains synonym
1 Adenosine deaminase A Adenosine aminohydrolase
ec: 3.5.4.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
tissue: intestine
Authors : Kinoshita, T.
Keywords : beta barrel, zinc, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structure-Based Design and Synthesis of Non-Nucleoside, Potent, and Orally Bioavailable Adenosine Deaminase Inhibitors

Terasaka, T.,Okumura, H.,Tsuji, K.  et al.
(2004)  J.Med.Chem.  47 : 2728 - 2731

PubMed: 15139750
DOI: 10.1021/jm0499559

Reaction

Chain : A
UniProt : P56658 (ADA_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine + H(+) + H2O = inosine + NH4(+) 3.5.4.4 UniProtKB:P00813
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2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) 3.5.4.4 UniProtKB:P00813
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