Brand  (β version)

PDB ID: 2DGN

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Ligands
Code Name Style Show Link
DOI 9-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-6-(phosphonooxy)-9h-purine PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2DGN   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Mouse Muscle Adenylosuccinate Synthetase partially ligated complex with GTP, 2'-deoxy-IMP
Release Data : 2006-09-15
Compound :
mol_id molecule chains synonym
1 Adenylosuccinate synthetase isozyme 1 A Adenylosuccinate synthetase, muscle isozyme, IMP--aspartate ligase 1, AdSS 1, AMPSase 1
ec: 6.3.4.4
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Iancu, C.V., Zhou, Y., Borza, T., Fromm, H.J., Honzatko, R.B.
Keywords : Adenylosuccinate synthetase, GTP, ADSS1, 2'-deoxy-IMP, Ligase
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.

Iancu, C.V.,Zhou, Y.,Borza, T.  et al.
(2006)  Biochemistry  45 : 11703 - 11711

PubMed: 16981730
DOI: 10.1021/bi0607498

Reaction

Chain : A
UniProt : P28650 (PURA1_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+) 6.3.4.4 HAMAP-Rule:MF_03126
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 1 Mg(2+) ion per subunit.