Brand  (β version)

PDB ID: 2C7V

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
MTX Methotrexate PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
NI Nickel (II) ion PoSSuM
Non-standard Residues
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CAF S-dimethylarsinoyl-cysteine
Glycosylation
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Structure summary

Code : 2C7V   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate
Release Data : 2006-09-19
Compound :
mol_id molecule chains
1 PTERIDINE REDUCTASE A,B,C,D
ec: 1.5.1.33
Source :
mol_id organism_scientific expression_system
1 TRYPANOSOMA BRUCEI BRUCEI  (taxid:5702) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PET15B
expression_system_plasmid: PET-TBPTR1H
Authors : Dawson, A., Gibellini, F., Sienkiewicz, N., Fyfe, P.K., McLuskey, K., Fairlamb, A.H., Hunter, W.N.
Keywords : PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate

Dawson, A.,Gibellini, F.,Sienkiewicz, N.  et al.
(2006)  Mol.Microbiol.  61 : 1457

PubMed: 16968221
DOI: 10.1111/J.1365-2958.2006.05332.X

Reaction

Chain : A, B, C, D
UniProt : O76290 (O76290_TRYBB)
Reaction : -