Brand  (β version)

PDB ID: 2C69

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Ligands
Code Name Style Show Link
CT8 (5z)-5-(3-bromocyclohexa-2,5-dien-1-ylidene)-N-(pyridin-4-ylmethyl)-1,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-7-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2C69   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
Release Data : 2005-12-07
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: Sf21
expression_system_vector_type: BACULOVIRUS
Authors : Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Keywords : TRANSFERASE, SERINE/THREONINE PROTEIN KINASE, CDK2, ATP-BINDING, CELL CYCLE, MITOSIS, PHOSPHORYLATION, TRIAZOLOPYRIMIDINE INHIBITOR, CELL DIVISION, KINASE, POLYMORPHISM, NUCLEOTIDE-BINDING
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

Richardson, C.M.,Williamson, D.S.,Parratt, M.J.  et al.
(2006)  Bioorg. Med. Chem. Lett.  16 : 1353 - 1357

PubMed: 16325401
DOI: 10.1016/j.bmcl.2005.11.048

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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