Het-PDB Navi2 (PDB: 2C57)

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Ligands
Code	Name		Style	Show	Link
FA1	2,3 -anhydro-quinic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2C57

Code :

2C57 PDBj RCSB PDB PDBe

Header :

LYASE

Title :

H.pylori type II dehydroquinase in complex with FA1

Release Data :

2006-02-22

Compound :

mol_id	molecule	chains	synonym
1	3-DEHYDROQUINATE DEHYDRATASE	A,B,C,D,E,F,G,H,I,J,K,L	3-DEHYDROQUINASE, TYPE II DHQASE
	ec: 4.2.1.10

Source :

mol_id	organism_scientific	expression_system
1	HELICOBACTER PYLORI (taxid:210)	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_variant: PLYSS expression_system_vector: PTB361 expression_system_plasmid: PET-15B

Authors :

Robinson, D.A., Lapthorn, A.J.

Keywords :

DEHYDROQUINASE, DEHYDROQUINATE, SULPHONAMIDE, LYASE, 3-DEHYDROQUINASE, SHIKIMATE PATHWAY, AROMATIC AMINO ACID BIOSYNTHESIS

Exp. method :

X-RAY DIFFRACTION ( 3.10 Å )

Citation :

Crystal Structures of Helicobacter Pylori Type II Dehydroquinase Inhibitor Complexes: New Directions for Inhibitor Design.

Robinson, D.A.,Stewart, K.A.,Price, N.C. et al.
(2006) J.Med.Chem. 49 : 1282

Chain :

A, B, C, D, E, F, G, H, I, J, K, L

UniProt :

Q48255 (AROQ_HELPY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
3-dehydroquinate = 3-dehydroshikimate + H2O	4.2.1.10	-
3-dehydroquinate = 3-dehydroshikimate + H2O	-	-

PDB ID: 2C57