PDB ID: 2C1B
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Structure summary
Code : | 2C1B PDBj RCSB PDB PDBe | ||||||||||||||||||||
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Header : | TRANSFERASE/INHIBITOR | ||||||||||||||||||||
Title : | Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-(4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline | ||||||||||||||||||||
Release Data : | 2005-11-02 | ||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Collins, I., Caldwell, J., Fonseca, T., Donald, A., Bavetsias, V., Hunter, L.J., Garrett, M.D., Rowlands, M.G., Aherne, G.W., Davies, T.G., Berdini, V., Woodhead, S.J., Seavers, L.C.A., Wyatt, P.G., Workman, P., McDonald, E. | ||||||||||||||||||||
Keywords : | TRANSFERASE/INHIBITOR, COMPLEX (TRANSFERASE-INHIBITOR), ATP-BINDING, CAMP, PHOSPHORYLATION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, PROTEIN KINASE INHIBITOR, TRANSFERASE-INHIBITOR complex | ||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.00 Å ) | ||||||||||||||||||||
Citation : |
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.
Collins, I.,Caldwell, J.,Fonseca, T.
et al.
PubMed: 16249095 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P00517 (KAPCA_BOVIN) | ||||||||||||
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Chain : | I |
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UniProt : | P61925 (IPKA_HUMAN) |
Reaction : | - |