Het-PDB Navi2 (PDB: 2C14)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show
CYJ	(z)-N~6~-[(4r,5s)-5-(2-carboxyethyl)-4-(carboxymethyl)piperidin-3-ylidene]-L-lysine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 2C14

Code :

2C14 PDBj RCSB PDB PDBe

Header :

LYASE

Title :

5-(4-Carboxy-2-oxo-butylamino)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa

Release Data :

2006-06-20

Compound :

mol_id	molecule	chains	synonym
1	DELTA-AMINOLEVULINIC ACID DEHYDRATASE	A,B	PORPHOBILINOGEN SYNTHASE, ALAD, ALADH
	ec: 4.2.1.24 mutation: YES

Source :

mol_id	organism_scientific	expression_system
1	PSEUDOMONAS AERUGINOSA (taxid:287)	ESCHERICHIA COLI (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector: PET3A

Authors :

Frere, F., Nentwich, M., Gacond, S., Heinz, D.W., Neier, R., Frankenberg-Dinkel, N.

Keywords :

ENZYME MECHANISM, METALLOENZYME, PORPHOBILINOGEN SYNTHASE, COCRYSTALLIZATION, LYASE, PORPHYRIN BIOSYNTHESIS

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors.

Frere, F.,Nentwich, M.,Gacond, S. et al.
(2006) Biochemistry 45 : 8243

Chain :

A, B

UniProt :

Q59643 (HEM2_PSEAE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen	4.2.1.24	PubMed:16819823
2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen	-	PubMed:16819823

PDB ID: 2C14