Brand  (β version)

PDB ID: 2BYB

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Ligands
Code Name Style Show Link
DPK Deprenyl PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2BYB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human Monoamine Oxidase B in complex with Deprenyl
Release Data : 2005-08-09
Compound :
mol_id molecule chains synonym
1 AMINE OXIDASE [FLAVIN-CONTAINING] B A,B MONOAMINE OXIDASE TYPE B, MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:4922)
Authors : Binda, C., De Colibus, L., Edmondson, D.E., Mattevi, A.
Keywords : OXIDOREDUCTASE, FAD-CONTAINING AMINE OXIDASE, MAOB ACETYLATION, FAD, FLAVOPROTEIN, MAOB, TRANSMEMBRANE NEUROTRANSMITTER, MEMBRANE-PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Three-Dimensional Structure of Human Monoamine Oxidase a (Mao A): Relation to the Structures of Rat Mao a and Human Mao B

De Colibus, L.,Li, M.,Binda, C.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 12864

PubMed: 16129825
DOI: 10.1073/PNAS.0505975102

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine - PubMed:20493079
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an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
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dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
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