Brand  (β version)

PDB ID: 2BXT

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Ligands
Code Name Style Show Link
C2D 6-chloro-1-(2-{[(5-chloro-1-benzothien-3-yl)methyl]amino}ethyl)-3-[(2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol PoSSuM
Non-standard Residues
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TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 2BXT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker
Release Data : 2006-10-26
Compound :
mol_id molecule chains synonym
1 ALPHA THROMBIN H COAGULATION FACTOR II
ec: 3.4.21.5
fragment: LARGE SUBUNIT, RESIDUES 364-622
mol_id molecule chains
2 HIRUDIN VARIANT-2 I
mol_id molecule chains synonym
3 ALPHA THROMBIN L COAGULATION FACTOR II
ec: 3.4.21.5
fragment: SMALL SUBUNIT, RESIDUES 328-363
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common
2 HIRUDO MEDICINALIS  (taxid:6421) MEDICINAL LEECH
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Bulat, S., Bosio, S., Grabowski, E., Papadopoulos, M.A., Cerezo-Galvez, S., Rosenbaum, C., Matassa, V.G., Ott, I., Metz, G., Schamberger, J., Sekul, R., Feurer, A.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.83 Å )
Citation :

Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker

Bulat, S.,Bosio, S.,Papadopoulos, M.A.  et al.
(2006)  Lett.Drug Des.Discovery  3 : 289

DOI: 10.2174/157018006777574203

Reaction

Chain : L
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P09945 (HIRV2_HIRME)
Reaction : -