PDB ID: 2BUB
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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FPB | N-({(2s)-1-[(3r)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl}methyl)benzamide | PoSSuM |
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NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose |
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Download interaction data: 2BUB
Structure summary
Code : | 2BUB PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/INHIBITOR | ||||||||||||
Title : | Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor | ||||||||||||
Release Data : | 2006-01-23 | ||||||||||||
Compound : |
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Authors : | Nordhoff, S., Cerezo-Galvez, S., Feurer, A., Hill, O., Matassa, V.G., Metz, G., Rummey, C., Thiemann, M., Edwards, P.J. | ||||||||||||
Keywords : | HYDROLASE/INHIBITOR, COMPLEX (HYDROLASE-INHIBITOR), DPP-IV, DIABETES MELLITUS, DRUG DESIGN, HYDROLASE, SERINE PROTEASE, AMINOPEPTIDASE, GLYCOPROTEIN, PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, COMPLEX, HYDROLASE-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.66 Å ) | ||||||||||||
Citation : |
The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.
Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.
et al.
PubMed: 16376544 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P27487 (DPP4_HUMAN) | ||||||||
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