Brand  (β version)

PDB ID: 2BUB

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Ligands
Code Name Style Show Link
FPB N-({(2s)-1-[(3r)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl}methyl)benzamide PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Structure summary

Code : 2BUB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/INHIBITOR
Title : Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor
Release Data : 2006-01-23
Compound :
mol_id molecule chains synonym
1 DIPEPTIDYL PEPTIDASE 4 A,B DIPEPTIDYL PEPTIDASE IV, DPP IV, T-CELL ACTIVATION ANTIGEN CD26, TP103, ADENOSINE DEAMINASE COMPLEXING PROTEIN-2
ec: 3.4.14.5
fragment: EXTRACELLULAR DOMAIN, RESIDUES 39-766
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA METHANOLICA  (taxid:33166)
Authors : Nordhoff, S., Cerezo-Galvez, S., Feurer, A., Hill, O., Matassa, V.G., Metz, G., Rummey, C., Thiemann, M., Edwards, P.J.
Keywords : HYDROLASE/INHIBITOR, COMPLEX (HYDROLASE-INHIBITOR), DPP-IV, DIABETES MELLITUS, DRUG DESIGN, HYDROLASE, SERINE PROTEASE, AMINOPEPTIDASE, GLYCOPROTEIN, PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, COMPLEX, HYDROLASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.66 Å )
Citation :

The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.

Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.  et al.
(2006)  Bioorg. Med. Chem. Lett.  16 : 1744 - 1748

PubMed: 16376544
DOI: 10.1016/j.bmcl.2005.11.103

Reaction

Chain : A, B
UniProt : P27487 (DPP4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 PROSITE-ProRule:PRU10084, PubMed:10593948
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