Brand  (β version)

PDB ID: 2BS4

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Ligands
Code Name Style Show Link
CIT Citric acid PoSSuM
DMW 2,3-dimethyl-1,4-naphthoquinone PoSSuM
F3S Fe3-s4 cluster PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
NA Sodium ion PoSSuM
SF4 Iron/sulfur cluster PoSSuM
LMT Dodecyl-beta-D-maltoside PoSSuM
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Structure summary

Code : 2BS4   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : GLU C180 -> ILE VARIANT QUINOL:FUMARATE REDUCTASE FROMWOLINELLA SUCCINOGENES
Release Data : 2005-12-13
Compound :
mol_id molecule chains
1 QUINOL-FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT A A,D
ec: 1.3.99.1
other_details: FAD COVALENTLY BOUND TO HIS A43 BY AN 8-ALPHA-(N-EPSILON-HISTIDYL) BOND
mol_id molecule chains
2 QUINOL-FUMARATE REDUCTASE IRON-SULFUR SUBUNIT B B,E
ec: 1.3.99.1
mol_id molecule chains
3 QUINOL-FUMARATE REDUCTASE DIHEME CYTOCHROME B SUBUNIT C C,F
ec: 1.3.99.1
Source :
mol_id organism_scientific
1 WOLINELLA SUCCINOGENES  (taxid:844)
mol_id organism_scientific
2 WOLINELLA SUCCINOGENES  (taxid:844)
mol_id organism_scientific
3 WOLINELLA SUCCINOGENES  (taxid:844)
Authors : Lancaster, C.R.D.
Keywords : 2FE-2S, 3FE-4S, 4FE-4S, CITRIC ACID CYCLE, DIHAEM CYTOCHROME B, ELECTRON TRANSPORT, FAD, FLAVOPROTEIN, FUMARATE REDUCTASE, HEME, ION-SULPHUR PROTEIN, IRON, IRON-SULFUR, METAL-BINDING, OXIDOREDUCTASE, RESPIRATORY CHAIN, SUCCINATE DEHYDROGENASE, TRANSMEMBRANE, TRICARBOXYLIC ACID CYCLE
Exp. method : X-RAY DIFFRACTION ( 2.76 Å )
Citation :

Experimental Support for the E-Pathway Hypothesis of Coupled Transmembrane Electron and Proton Transfer in Dihemic Quinol:Fumarate Reductase

Lancaster, C.R.D.,Sauer, U.S.,Gross, R.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 18860

PubMed: 16380425
DOI: 10.1073/PNAS.0509711102

Wolinella Succinogenes Quinol:Fumarate Reductase and its Comparison to E. Coli Succinate:Quinone Reductase

Lancaster, C.R.D.
(2003)  FEBS Lett.  555 : 21

PubMed: 14630313
DOI: 10.1016/S0014-5793(03)01100-1

Wolinella Succinogenes Quinol:Fumarate Reductase -2.2 Angstrom Resolution Crystal Structure and the E-Pathway Hypothesis of Coupled Transmembrane Proton and Electron Transfer

Lancaster, C.R.D.
(2002)  Biochim.Biophys.Acta  1565 : 215

PubMed: 12409197
DOI: 10.1016/S0005-2736(02)00571-0

A Third Crystal Form of Wolinella Succinogenes Quinol:Fumarate Reductase Reveals Domain Closure at the Site of Fumarate Reduction

Lancaster, C.R.D.,Gross, R.,Simon, J.
(2001)  Eur.J.Biochem.  268 : 1820

PubMed: 11248702
DOI: 10.1046/J.1432-1327.2001.02053.X

Essential Role of Glu-C66 for Menaquinol Oxidation Indicates Transmembrane Electrochemical Potential Generation by Wolinella Succinogenes Fumarate Reductase

Lancaster, C.R.D.,Gross, R.,Haas, A.  et al.
(2000)  Proc.Natl.Acad.Sci.USA  97 : 13051

PubMed: 11186225
DOI: 10.1073/PNAS.220425797

Structure of Fumarate Reductase from Wolinella Succinogenes at 2.2 Angstroms Resolution

Lancaster, C.R.D.,Kroeger, A.,Auer, M.  et al.
(1999)  Nature  402 : 377

PubMed: 10586875
DOI: 10.1038/46483

Reaction

Chain : A, D
UniProt : P17412 (FRDA_WOLSU)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 -
-
Chain : B, E
UniProt : P17596 (FRDB_WOLSU)
Reaction: EC: Evidence:
Physiological Direction:
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 UniProtKB:P0AC47
-
Chain : C, F
UniProt : P17413 (FRDC_WOLSU)
Reaction : -