Brand  (β version)

PDB ID: 2BLB

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Ligands
Code Name Style Show Link
CP7 6-ethyl-5-phenylpyrimidine-2,4-diamine PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
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Structure summary

Code : 2BLB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Release Data : 2005-09-07
Compound :
mol_id molecule chains synonym
1 DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE A DIHYDROFOLATE REDUCTASE
ec: 1.5.1.3
Source :
mol_id organism_scientific expression_system
1 PLASMODIUM VIVAX  (taxid:5855) ESCHERICHIA COLI  (taxid:562)
Authors : Kongsaeree, P., Khongsuk, P., Leartsakulpanich, U., Chitnumsub, P., Tarnchompoo, B., Walkinshaw, M.D., Yuthavong, Y.
Keywords : DIHYDROFOLATE REDUCTASE, PLAMODIUM VIVAX, PYRIMETHAMINE, MALARIA, DRUG RESISTANCE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.

Kongsaeree, P.,Khongsuk, P.,Leartsakulpanich, U.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 13046

PubMed: 16135570
DOI: 10.1073/PNAS.0501747102

Reaction

Chain : A
UniProt : Q9TW60 (Q9TW60_PLAVI)
Reaction: EC: Evidence:
Physiological Direction:
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8- dihydrofolate + dTMP 2.1.1.45 ARBA:ARBA00047344
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