Brand  (β version)

PDB ID: 2BK3

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
FOF (2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2BK3   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human Monoamine Oxidase B in complex with Farnesol
Release Data : 2005-02-14
Compound :
mol_id molecule chains synonym
1 AMINE OXIDASE [FLAVIN-CONTAINING] B A,B HUMAN MONOAMINE OXIDASE B, MONOAMINE OXIDASE, MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN PICHIA PASTORIS  (taxid:4922)
Authors : Binda, C., Edmondson, D.E., Mattevi, A.
Keywords : ACETYLATION, FARNESOL, FAD, FAD-CONTAINING AMINE OXIDASE, FLAVOPROTEIN, MAOB, MITOCHONDRION, OXIDOREDUCTASE, TRANSMEMBRANE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.

Hubalek, F.,Binda, C.,Khalil, A.  et al.
(2005)  J. Biol. Chem.  280 : 15761 - 15766

PubMed: 15710600
DOI: 10.1074/jbc.M500949200

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2 - PubMed:20493079
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a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
left-to-right
dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:11753429
ECO:0000269 | PubMed:12913124
ECO:0000269 | PubMed:15027868
ECO:0000269 | PubMed:15710600
ECO:0000269 | PubMed:16366596
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