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Ligands
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JS5 (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-((2r,3r,4r,5s)-5-((1r,2r,3s,5r,6s)-3,5-diamino-2-((2s,3r,4r,5s,6r)-3-amino-4 ,5-dihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-yloxy)-6-hydroxycyclohexyloxy)-2-(hydroxymethyl)-4-(2-((R)-piperidi N-3-ylmethylamino)ethoxy)-tetrahydrofuran-3-yloxy)-tetrahydro-2h-pyran-3,4-diol
Non-standard Residues
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Glycosylation
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Code : 2BE0   PDBj   RCSB PDB   PDBe
Header : RNA/antibiotic
Title : Complex Between Paromomycin Derivative JS5-39 and the 16S-Rrna A-Site.
Release Data : 2005-12-20
Compound :
mol_id molecule chains
1 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' A,B
other_details: 16S Rrna A Site
Source :
mol_id organism_scientific
1 Streptomyces rimosus subsp. paromomycinus  (taxid:92743)
synthetic: yes
Authors : Francois, B., Westhof, E.
Keywords : RNA-AMINOGLYCOSIDE INTERACTIONS, A SITE, UOU PAIRS, AA BULGES, RNA-antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 2.63 Å )
Citation :

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site

Francois, B.,Szychowski, J.,Adhikari, S.S.  et al.
(2004)  ANGEW.CHEM.INT.ED.ENGL.  43 : 6735 - 6738

PubMed: 15593140
DOI: 10.1002/anie.200462092