Brand  (β version)

PDB ID: 2B60

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
RIT Ritonavir PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2B60   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structure of HIV-1 protease mutant bound to Ritonavir
Release Data : 2006-11-14
Compound :
mol_id molecule chains
1 Gag-Pol polyprotein A,B
fragment: Protease
mutation: K20R, V32I, L33F, M36I, L63P, A71V, V82A, L90M
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
expression_system_strain: BL21 Star DE3 pLysS
expression_system_plasmid: pET23a
Authors : Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
Keywords : HIV-1 protease, protease inhibitors, ritonavir, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

In vivo, kinetic, and structural analysis of the development of ritonavir resistance

Clemente, J.C.,Stow, L.R.,Janka, L.K.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : Q7SMT3 (Q7SMT3_9HIV1)
Reaction: EC: Evidence:
Physiological Direction:
Endonucleolytic cleavage to 5'-phosphomonoester. 3.1.26.4 ARBA:ARBA00000077
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