Het-PDB Navi2 (PDB: 2AUZ)

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Ligands
Code	Name		Style	Show	Link
CT2	1-(phenylmethyl)cyclopentyl[(1s)-1-formylpentyl]carbamate				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
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Download interaction data: 2AUZ

Code :

2AUZ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Cathepsin K complexed with a semicarbazone inhibitor

Release Data :

2006-08-08

Compound :

mol_id	molecule	chains	synonym
1	Cathepsin K	A	Cathepsin O, Cathepsin X, Cathepsin O2
	ec: 3.4.22.38 fragment: mature form of cathepsin K (residues 115-329)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CTSK, CTSO, CTSO2 expression_system_common: Fall armyworm expression_system_vector_type: baculovirus expression_system_plasmid: pFastbac

Authors :

Adkison, K.K., Barrett, D.G., Deaton, D.N., Gampe, R.T., Hassell, A.M., Long, S.T., McFadyen, R.B., Miller, A.B., Miller, L.R., Shewchuk, L.M.

Keywords :

catK, cysteine protease, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Adkison, K.K.,Barrett, D.G.,Deaton, D.N. et al.
(2006) Bioorg.Med.Chem.Lett. 16 : 978 - 983

Chain :

UniProt :

P43235 (CATK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.	3.4.22.38	-
	-	-

PDB ID: 2AUZ