Het-PDB Navi2 (PDB: 2ANM)

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Ligands
Code	Name		Style	Show	Link
CDO	2-((R)-1-((S)-2-(N-(6-carbamimidoylpyridin-3-yl)methylcarbamoyl)-2h-pyrrol-1(5h)-yl)-3-cyclohexyl-1-oxopropan-2-ylamino)acetic acid				PoSSuM

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Download interaction data: 2ANM

Code :

2ANM PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING

Title :

Ternary complex of an orally active thrombin inhibitor with human thrombin and a C-terminal hirudin derived exo-sit inhibitor

Release Data :

2006-06-13

Compound :

mol_id	molecule	chains	synonym
1	thrombin	H	Coagulation factor II
	ec: 3.4.21.5 fragment: Thrombin heavy chain

mol_id	molecule	chains	synonym
2	thrombin	L	Coagulation factor II
	ec: 3.4.21.5 fragment: Thrombin light chain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Lange, U.E.W., Baucke, D., Hornberger, W., Mack, H., Seitz, W., Hoeffken, H.W.

Keywords :

BLOOD CLOTTING

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety

Lange, U.E.W.,Baucke, D.,Hornberger, W. et al.
(2006) Bioorg.Med.Chem.Lett. 16 : 2648 - 2653

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 2ANM